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Scalalactams A?D, Scalarane Sesterterpenes with a ?-Lactam Moiety from a Korean Spongia Sp. Marine Sponge.

ABSTRACT: Intensive study on the chemical components of a Korean marine sponge, Spongia sp., has led to the isolation of four new scalarane sesterterpenes, scalalactams A?D (1?4). Their chemical structures were elucidated from the analysis of spectroscopic data including 1D-and 2D-NMR as well as MS data. Scalalactams A?D (1?4) possess a scalarane carbon skeleton with a rare structural feature of a ?-lactam moiety within the molecules. Scalalactams A and B (1 and 2) have an extended isopropanyl chain at the lactam ring, and scalalactams C and D (3 and 4) possess a phenethyl group at the lactam ring moiety. Scalalactams A?D (1?4) did not show FXR antagonistic activity nor cytotoxicity up to 100 ?M.

SUBMITTER: Yang I

PROVIDER: S-EPMC6321518 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Scalalactams A⁻D, Scalarane Sesterterpenes with a γ-Lactam Moiety from a Korean Spongia Sp. Marine Sponge.

Yang Inho I Lee Jusung J Lee Jihye J Hahn Dongyup D Chin Jungwook J Won Dong Hwan DH Ko Jaeyoung J Choi Hyukjae H Hong Ahreum A Nam Sang-Jip SJ Kang Heonjoong H

Molecules (Basel, Switzerland) 20181203 12

Intensive study on the chemical components of a Korean marine sponge, Spongia sp., has led to the isolation of four new scalarane sesterterpenes, scalalactams A⁻D (1⁻4). Their chemical structures were elucidated from the analysis of spectroscopic data including 1D-and 2D-NMR as well as MS data. Scalalactams A⁻D (1⁻4) possess a scalarane carbon skeleton with a rare structural feature of a γ-lactam moiety within the molecules. Scalalactams A and B (1 and < ...[more]

PMID: 30513974

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