Ontology highlight
ABSTRACT:
SUBMITTER: Krachtus D
PROVIDER: S-EPMC6321591 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Krachtus Dieter D Smith Jeremy C JC Imhof Petra P
Molecules (Basel, Switzerland) 20181217 12
Phosphoserine phosphatase (PSP), a member of the haloacid dehalogenase (HAD) superfamily that comprises the vast majority of phosphotransferases, is likely a steady-state regulator of the level of d-serine in the brain. The proposed catalytic cycle of PSP consists of a two-step mechanism: formation of a phospho-enzyme intermediate by phosphate transfer to Asp11 and its subsequent hydrolysis. Our combined quantum mechanical/molecular mechanical (QM/MM) calculations of the reaction pathways favour ...[more]