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Epigenome-wide association study of serum cotinine in current smokers reveals novel genetically driven loci.

ABSTRACT: BACKGROUND:DNA methylation alteration extensively associates with smoking and is a plausible link between smoking and adverse health. We examined the association between epigenome-wide DNA methylation and serum cotinine levels as a proxy of nicotine exposure and smoking quantity, assessed the role of SNPs in these associations, and evaluated molecular mediation by methylation in a sample of biochemically verified current smokers (N?=?310). RESULTS:DNA methylation at 50 CpG sites was associated (FDR

SUBMITTER: Gupta R 

PROVIDER: S-EPMC6321663 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Epigenome-wide association study of serum cotinine in current smokers reveals novel genetically driven loci.

Gupta Richa R   van Dongen Jenny J   Fu Yu Y   Abdellaoui Abdel A   Tyndale Rachel F RF   Velagapudi Vidya V   Boomsma Dorret I DI   Korhonen Tellervo T   Kaprio Jaakko J   Loukola Anu A   Ollikainen Miina M  

Clinical epigenetics 20190105 1

<h4>Background</h4>DNA methylation alteration extensively associates with smoking and is a plausible link between smoking and adverse health. We examined the association between epigenome-wide DNA methylation and serum cotinine levels as a proxy of nicotine exposure and smoking quantity, assessed the role of SNPs in these associations, and evaluated molecular mediation by methylation in a sample of biochemically verified current smokers (N = 310).<h4>Results</h4>DNA methylation at 50 CpG sites w  ...[more]

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