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Subclinical tuberculosis among adults with HIV: clinical features and outcomes in a South African cohort.


ABSTRACT: BACKGROUND:Subclinical tuberculosis is an asymptomatic disease phase with important relevance to persons living with HIV. We describe the prevalence, clinical characteristics, and risk of mortality for HIV-infected adults with subclinical tuberculosis. METHODS:Untreated adults with HIV presenting for outpatient care in Durban, South Africa were screened for tuberculosis-related symptoms and had sputum tested by acid-fast bacilli smear and tuberculosis culture. Active tuberculosis and subclinical tuberculosis were defined as having any tuberculosis symptom or no tuberculosis symptoms with culture-positive sputum. We evaluated the association between tuberculosis disease category and 12-month survival using Cox regression, adjusting for age, sex, and CD4 count. RESULTS:Among 654 participants, 96 were diagnosed with active tuberculosis disease and 28 with subclinical disease. The median CD4 count was 68 (interquartile range 39-161) cells/mm3 in patients with active tuberculosis, 136 (72-312) cells/mm3 in patients with subclinical disease, and 249 (125-394) cells/mm3 in those without tuberculosis disease (P?

SUBMITTER: Bajema KL 

PROVIDER: S-EPMC6321698 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Subclinical tuberculosis among adults with HIV: clinical features and outcomes in a South African cohort.

Bajema Kristina L KL   Bassett Ingrid V IV   Coleman Sharon M SM   Ross Douglas D   Freedberg Kenneth A KA   Wald Anna A   Drain Paul K PK  

BMC infectious diseases 20190105 1


<h4>Background</h4>Subclinical tuberculosis is an asymptomatic disease phase with important relevance to persons living with HIV. We describe the prevalence, clinical characteristics, and risk of mortality for HIV-infected adults with subclinical tuberculosis.<h4>Methods</h4>Untreated adults with HIV presenting for outpatient care in Durban, South Africa were screened for tuberculosis-related symptoms and had sputum tested by acid-fast bacilli smear and tuberculosis culture. Active tuberculosis  ...[more]

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