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A General Approach to Biocompatible Branched Fluorous Tags for Increased Solubility in Perfluorocarbon Solvents.

ABSTRACT: A modular, cost-effective route to a library of branched fluorous tags with two short, biocompatible, fluorinated chains (C6F13) is reported. These branched fluorous tags provide high fluorous content without the use of long-chain linear perfluorocarbons, which have rising health concerns due to their bioaccumulation. By attaching these tags to a porphyrin, it is demonstrated that high solubility can be achieved in fluorous solvents that are readily cleared from mammals. This work enhances the biocompatibility of perfluorocarbon nanoemulsions for photodynamic therapy.

SUBMITTER: Miller MA

PROVIDER: S-EPMC6321771 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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A General Approach to Biocompatible Branched Fluorous Tags for Increased Solubility in Perfluorocarbon Solvents.

Miller Margeaux A MA Sletten Ellen M EM

Organic letters 20181024 21

A modular, cost-effective route to a library of branched fluorous tags with two short, biocompatible, fluorinated chains (C<sub>6</sub>F<sub>13</sub>) is reported. These branched fluorous tags provide high fluorous content without the use of long-chain linear perfluorocarbons, which have rising health concerns due to their bioaccumulation. By attaching these tags to a porphyrin, it is demonstrated that high solubility can be achieved in fluorous solvents that are readily cleared from mammals. Th ...[more]

PMID: 30354161

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