Ontology highlight
ABSTRACT:
SUBMITTER: Schwartz DA
PROVIDER: S-EPMC6322034 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Annals of the American Thoracic Society 20181101 Suppl 3
Idiopathic pulmonary fibrosis (IPF) is localized to the lung, is characterized by a pattern of heterogeneous, subpleural patches of fibrotic, remodeled lung, and is associated with a median survival of 3-5 years after diagnosis. A common gain-of-function MUC5B promoter variant, rs35705950, is the strongest risk factor (genetic and otherwise), accounting for at least 30% of the total risk of developing IPF. The MUC5B promoter variant can be used to identify individuals in the preclinical phase of ...[more]