Ontology highlight
ABSTRACT:
SUBMITTER: Vo AH
PROVIDER: S-EPMC6322066 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Vo Andy H AH Swaggart Kayleigh A KA Woo Anna A Gao Quan Q QQ Demonbreun Alexis R AR Fallon Katherine S KS Quattrocelli Mattia M Hadhazy Michele M Page Patrick G T PGT Chen Zugen Z Eskin Ascia A Squire Kevin K Nelson Stanley F SF McNally Elizabeth M EM
Human molecular genetics 20190101 2
Like other single-gene disorders, muscular dystrophy displays a range of phenotypic heterogeneity even with the same primary mutation. Identifying genetic modifiers capable of altering the course of muscular dystrophy is one approach to deciphering gene-gene interactions that can be exploited for therapy development. To this end, we used an intercross strategy in mice to map modifiers of muscular dystrophy. We interrogated genes of interest in an interval on mouse chromosome 10 associated with b ...[more]