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CART cell therapy for prostate cancer: status and promise.


ABSTRACT: In recent years, the, chimeric antigen receptor T (CAR-T) cell therapy as an adoptive immunotherapy has received great attention and made great breakthroughs. CAR-T cells show great specificity, targeting, and less major histocompatibility complex restriction in tumor immunotherapy, significantly different from traditional T cells. In spite of the progress of CART-T technology in the treatment of lymphoma, leukemia, and other blood system tumor, there are still many difficulties in the treatment of solid tumors by CAR-T technology. In this review, we will make a brief summary of the present situation of CAR-T cells in the treatment of prostate cancer, and discuss the promise of the application of this technology to prostate cancer therapy.

SUBMITTER: Yu H 

PROVIDER: S-EPMC6322708 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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CART cell therapy for prostate cancer: status and promise.

Yu Haiyuan H   Pan Jun J   Guo Zhicheng Z   Yang Chunhua C   Mao Lijun L  

OncoTargets and therapy 20190103


In recent years, the, chimeric antigen receptor T (CAR-T) cell therapy as an adoptive immunotherapy has received great attention and made great breakthroughs. CAR-T cells show great specificity, targeting, and less major histocompatibility complex restriction in tumor immunotherapy, significantly different from traditional T cells. In spite of the progress of CART-T technology in the treatment of lymphoma, leukemia, and other blood system tumor, there are still many difficulties in the treatment  ...[more]

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