Ontology highlight
ABSTRACT:
SUBMITTER: Wang F
PROVIDER: S-EPMC6322886 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Wang Fang F Zhao Kailiang K Yu Sixiang S Xu An A Han Wei W Mei Yide Y
The Journal of biological chemistry 20181109 1
RNA polymerase III (Pol III) is responsible for the production of small noncoding RNA species, including tRNAs and 5S rRNA. Pol III-dependent transcription is generally enhanced in transformed cells and tumors, but the underlying mechanisms remain not well-understood. It has been demonstrated that the BRF1 subunit of TFIIIB is essential for the accurate initiation of Pol III-dependent transcription. However, it is not known whether BRF1 undergoes ubiquitin modification and whether BRF1 ubiquitin ...[more]