NOTUM inhibition increases endocortical bone formation and bone strength.
Ontology highlight
ABSTRACT:
SUBMITTER: Brommage R
PROVIDER: S-EPMC6323125 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
NOTUM inhibition increases endocortical bone formation and bone strength.
Brommage Robert R Liu Jeff J Vogel Peter P Mseeh Faika F Thompson Andrea Y AY Potter David G DG Shadoan Melanie K MK Hansen Gwenn M GM Jeter-Jones Sabrina S Cui Jie J Bright Dawn D Bardenhagen Jennifer P JP Doree Deon D DD Movérare-Skrtic Sofia S Nilsson Karin H KH Henning Petra P Lerner Ulf H UH Ohlsson Claes C Sands Arthur T AT Tarver James E JE Powell David R DR Zambrowicz Brian B Liu Qingyun Q
Bone research 20190108
The disability, mortality and costs caused by non-vertebral osteoporotic fractures are enormous. Existing osteoporosis therapies are highly effective at reducing vertebral but not non-vertebral fractures. Cortical bone is a major determinant of non-vertebral bone strength. To identify novel osteoporosis drug targets, we phenotyped cortical bone of 3 366 viable mouse strains with global knockouts of druggable genes. Cortical bone thickness was substantially elevated in <i>Notum</i> <sup><i>-/-</i ...[more]
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