Ontology highlight
ABSTRACT:
SUBMITTER: Kok T
PROVIDER: S-EPMC6323139 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Kok Tjie T Wapenaar Hannah H Wang Kan K Neochoritis Constantinos G CG Zarganes-Tzitzikas Tryfon T Proietti Giordano G Eleftheriadis Nikolaos N Kurpiewska Katarzyna K Kalinowska-Tłuścik Justyna J Cool Robbert H RH Poelarends Gerrit J GJ Dömling Alexander A Dekker Frank J FJ
Bioorganic & medicinal chemistry 20171224 5
Macrophage migration inhibitory factor (MIF) is an essential signaling cytokine with a key role in the immune system. Binding of MIF to its molecular targets such as, among others, the cluster of differentiation 74 (CD74) receptor plays a key role in inflammatory diseases and cancer. Therefore, the identification of MIF binding compounds gained importance in drug discovery. In this study, we aimed to discover novel MIF binding compounds by screening of a focused compound collection for inhibitio ...[more]