Ontology highlight
ABSTRACT:
SUBMITTER: Bovijn J
PROVIDER: S-EPMC6323625 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Bovijn Jonas J Jackson Leigh L Censin Jenny J Chen Chia-Yen CY Laisk Triin T Laber Samantha S Ferreira Teresa T Pulit Sara L SL Glastonbury Craig A CA Smoller Jordan W JW Harrison Jamie W JW Ruth Katherine S KS Beaumont Robin N RN Jones Samuel E SE Tyrrell Jessica J Wood Andrew R AR Weedon Michael N MN Mägi Reedik R Neale Benjamin B Lindgren Cecilia M CM Murray Anna A Holmes Michael V MV
American journal of human genetics 20181221 1
Erectile dysfunction (ED) is a common condition affecting more than 20% of men over 60 years, yet little is known about its genetic architecture. We performed a genome-wide association study of ED in 6,175 case subjects among 223,805 European men and identified one locus at 6q16.3 (lead variant rs57989773, OR 1.20 per C-allele; p = 5.71 × 10<sup>-14</sup>), located between MCHR2 and SIM1. In silico analysis suggests SIM1 to confer ED risk through hypothalamic dysregulation. Mendelian randomizati ...[more]