MethMotif: an integrative cell specific database of transcription factor binding motifs coupled with DNA methylation profiles.

ABSTRACT: Several recent studies have portrayed DNA methylation as a new player in the recruitment of transcription factors (TF) within chromatin, highlighting a need to connect TF binding sites (TFBS) with their respective DNA methylation profiles. However, current TFBS databases are restricted to DNA binding motif sequences. Here, we present MethMotif, a two-dimensional TFBS database that records TFBS position weight matrices along with cell type specific CpG methylation information computed from a combination of ChIP-seq and whole genome bisulfite sequencing datasets. Integrating TFBS motifs with TFBS DNA methylation better portrays the features of DNA loci recognised by TFs. In particular, we found that DNA methylation patterns within TFBS can be cell specific (e.g. MAFF). Furthermore, for a giv

SUBMITTER: Xuan Lin QX 

PROVIDER: S-EPMC6323897 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature