IID 2018 update: context-specific physical protein-protein interactions in human, model organisms and domesticated species.

ABSTRACT: Knowing the set of physical protein-protein interactions (PPIs) that occur in a particular context-a tissue, disease, or other condition-can provide valuable insights into key research questions. However, while the number of identified human PPIs is expanding rapidly, context information remains limited, and for most non-human species context-specific networks are completely unavailable. The Integrated Interactions Database (IID) provides one of the most comprehensive sets of context-specific human PPI networks, including networks for 133 tissues, 91 disease conditions, and many other contexts. Importantly, it also provides context-specific networks for 17 non-human species including model organisms and domesticated animals. These species are vitally important for drug discovery and agricu

SUBMITTER: Kotlyar M 

PROVIDER: S-EPMC6323934 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature