Dataset Information

SAGD: a comprehensive sex-associated gene database from transcriptomes.

ABSTRACT: Many animal species present sex differences. Sex-associated genes (SAGs), which have female-biased or male-biased expression, have major influences on the remarkable sex differences in important traits such as growth, reproduction, disease resistance and behaviors. However, the SAGs resulting in the vast majority of phenotypic sex differences are still unknown. To provide a useful resource for the functional study of SAGs, we manually curated public RNA-seq datasets with paired female and male biological replicates from the same condition and systematically re-analyzed the datasets using standardized methods. We identified 27,793 female-biased SAGs and 64,043 male-biased SAGs from 2,828 samples of 21 species, including human, chimpanzee, macaque, mouse, rat, cow, horse, chicken, zebrafish, seven fly species and five worm species. All these data were cataloged into SAGD, a user-friendly database of SAGs (http://bioinfo.life.hust.edu.cn/SAGD) where users can browse SAGs by gene, species, drug and dataset. In SAGD, the expression, annotation, targeting drugs, homologs, ontology and related RNA-seq datasets of SAGs are provided to help researchers to explore their functions and potential applications in agriculture and human health.

SUBMITTER: Shi MW

PROVIDER: S-EPMC6323940 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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SAGD: a comprehensive sex-associated gene database from transcriptomes.

Shi Meng-Wei MW Zhang Na-An NA Shi Chuan-Ping CP Liu Chun-Jie CJ Luo Zhi-Hui ZH Wang Dan-Yang DY Guo An-Yuan AY Chen Zhen-Xia ZX

Nucleic acids research 20190101 D1

Many animal species present sex differences. Sex-associated genes (SAGs), which have female-biased or male-biased expression, have major influences on the remarkable sex differences in important traits such as growth, reproduction, disease resistance and behaviors. However, the SAGs resulting in the vast majority of phenotypic sex differences are still unknown. To provide a useful resource for the functional study of SAGs, we manually curated public RNA-seq datasets with paired female and male b ...[more]

PMID: 30380119

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Dataset Information

SAGD: a comprehensive sex-associated gene database from transcriptomes.

Publications

SAGD: a comprehensive sex-associated gene database from transcriptomes.

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