CancerSplicingQTL: a database for genome-wide identification of splicing QTLs in human cancer.

ABSTRACT: Alternative splicing (AS) is a widespread process that increases structural transcript variation and proteome diversity. Aberrant splicing patterns are frequently observed in cancer initiation, progress, prognosis and therapy. Increasing evidence has demonstrated that AS events could undergo modulation by genetic variants. The identification of splicing quantitative trait loci (sQTLs), genetic variants that affect AS events, might represent an important step toward fully understanding the contribution of genetic variants in disease development. However, no database has yet been developed to systematically analyze sQTLs across multiple cancer types. Using genotype data from The Cancer Genome Atlas and corresponding AS values calculated by TCGASpliceSeq, we developed a computational pipeline

SUBMITTER: Tian J 

PROVIDER: S-EPMC6324030 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature