Ontology highlight
ABSTRACT:
SUBMITTER: Jones SM
PROVIDER: S-EPMC6324171 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Jones Shannon M SM Mann Adrien A Conrad Kelsey K Saum Keith K Hall David E DE McKinney Lisa M LM Robbins Nathan N Thompson Joel J Peairs Abigail D AD Camerer Eric E Rayner Katey J KJ Tranter Michael M Mackman Nigel N Owens A Phillip AP
Arteriosclerosis, thrombosis, and vascular biology 20180329 6
<h4>Objective</h4>PAR2 (protease-activated receptor 2)-dependent signaling results in augmented inflammation and has been implicated in the pathogenesis of several autoimmune conditions. The objective of this study was to determine the effect of PAR2 deficiency on the development of atherosclerosis.<h4>Approach and results</h4>PAR2 mRNA and protein expression is increased in human carotid artery and mouse aortic arch atheroma versus control carotid and aortic arch arteries, respectively. To dete ...[more]