Dataset Information

Evaluation of Amphetamine-Related Hospitalizations and Associated Clinical Outcomes and Costs in the United States.

ABSTRACT:

Importance

Despite indications of increasing amphetamine availability and psychostimulant deaths in the United States, evidence across data sources is mixed, and data on amphetamine-related hospitalizations are lacking.

Objective

To clarify trends in amphetamine-related hospitalizations and their clinical outcomes and costs in the United States.

Design, setting, and participants

This repeated, cross-sectional study used hospital discharge data from the Healthcare Cost and Utilization Project National Inpatient Sample. The nationally representative sample included US adults (n?=?1?292?300) who had amphetamine-related hospitalizations between January 1, 2003, and December 31, 2015. Multivariable logistic and Poisson regression models were used to examine in-hospital mortality and length of stay. Analysis of these data was conducted from November 2017 to August 2018.

Exposure

Amphetamine dependence or abuse or amphetamine poisoning.

Main outcomes and measures

Annual hospitalizations, in-hospital mortality, length of stay, transfer to another facility, and costs.

Results

Over the 2003 to 2015 study period, there were 1?292?300 weighted amphetamine-related hospitalizations. Of this population, 541 199 (41.9%) were female and 749 392 (58.1%) were male, with a mean age of 37.5 years (95% CI, 37.4-37.7 years). Amphetamine-related hospitalizations, compared with other hospitalizations, were associated with age younger than 65 years (98.0% vs 58.0%; P?Conclusions and relevanceGiven that amphetamine-related hospitalizations and costs substantially increased between 2003 and 2015, pharmacologic and nonpharmacologic therapies for amphetamine use disorders and a coordinated public health response are needed to curb these rising rates.

SUBMITTER: Winkelman TNA

PROVIDER: S-EPMC6324446 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Publications

Evaluation of Amphetamine-Related Hospitalizations and Associated Clinical Outcomes and Costs in the United States.

Winkelman Tyler N A TNA Admon Lindsay K LK Jennings Latasha L Shippee Nathan D ND Richardson Caroline R CR Bart Gavin G

JAMA network open 20181005 6

<h4>Importance</h4>Despite indications of increasing amphetamine availability and psychostimulant deaths in the United States, evidence across data sources is mixed, and data on amphetamine-related hospitalizations are lacking.<h4>Objective</h4>To clarify trends in amphetamine-related hospitalizations and their clinical outcomes and costs in the United States.<h4>Design, setting, and participants</h4>This repeated, cross-sectional study used hospital discharge data from the Healthcare Cost and U ...[more]

PMID: 30646256

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Project description:BackgroundOsteoporotic fractures frequently require inpatient care, and are associated with elevated risks of morbidity, mortality, and re-hospitalization. A comprehensive evaluation of healthcare costs, resource utilization, and outcomes associated with osteoporosis (OP)-related fractures treated in US hospitals was undertaken.MethodsA retrospective analysis using the Premier Perspective Database (2010 - 2013) was conducted. Study population comprised patients aged ≥ 50 years hospitalized with a principal diagnosis of a closed or pathologic fracture commonly associated with OP; the first qualifying hospitalization was designated the "index admission". Patients with evidence of major trauma, malignancy, or other non-OP conditions that may lead to pathologic fracture during the index admission were excluded. Study measures included healthcare costs (in 2013 USD), length of stay (LOS), intensive care unit (ICU) use, and mortality during the index admission, as well as 60-day fracture-related readmission.ResultsA total of 268,477 patients were admitted to hospital (n = 548 hospitals) with a principal diagnosis of an OP-related fracture; mean (SD) age was 78 (11) years, 75% were female, 69% had ≥ 2 comorbidities, and 82% of patients had a diagnostic code for accidental fall. Among all OP-related fracture admissions, mean (95% CI) hospital cost was $12,839 (12,784-12,893) and LOS was 5.1 (5.1-5.1) days; during the admission, ICU use was 7.4% (7.3-7.5) and mortality was 1.5% (1.5-1.6), and during the 60-day post-discharge period, fracture-related readmission was 2.3% (2.2-2.4).ConclusionsHospital costs associated with the acute treatment of OP-related fractures are substantial, especially among patients with fractures of the hip, femur, and spine. Among patients with vertebral fractures-the second most common reason for admission-mortality and ICU use were notably high, and costs and LOS were higher than among those with non-vertebral fractures (excluding hip). Interventions that are effective in reducing fracture risk have the potential to yield substantial cost savings.

Dataset Information

Evaluation of Amphetamine-Related Hospitalizations and Associated Clinical Outcomes and Costs in the United States.

Importance

Objective

Design, setting, and participants

Exposure

Main outcomes and measures

Results

Publications

Evaluation of Amphetamine-Related Hospitalizations and Associated Clinical Outcomes and Costs in the United States.

Similar Datasets

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