Ontology highlight
ABSTRACT:
SUBMITTER: Roukos V
PROVIDER: S-EPMC6324928 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Roukos Vassilis V Voss Ty C TC Schmidt Christine K CK Lee Seungtaek S Wangsa Darawalee D Misteli Tom T
Science (New York, N.Y.) 20130801 6146
Chromosome translocations are a hallmark of cancer cells. We have developed an experimental system to visualize the formation of translocations in living cells and apply it to characterize the spatial and dynamic properties of translocation formation. We demonstrate that translocations form within hours of the occurrence of double-strand breaks (DSBs) and that their formation is cell cycle-independent. Translocations form preferentially between prepositioned genome elements, and perturbation of ...[more]