Ontology highlight
ABSTRACT:
SUBMITTER: Mulati K
PROVIDER: S-EPMC6325144 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Mulati Kumuluzi K Hamanishi Junzo J Matsumura Noriomi N Chamoto Kenji K Mise Nathan N Abiko Kaoru K Baba Tsukasa T Yamaguchi Ken K Horikawa Naoki N Murakami Ryusuke R Taki Mana M Budiman Kharma K Zeng Xiang X Hosoe Yuko Y Azuma Miyuki M Konishi Ikuo I Mandai Masaki M
British journal of cancer 20181109 1
<h4>Background</h4>V-domain Ig suppressor of T cell activation (VISTA) is a novel inhibitory immune-checkpoint protein. VISTA expression on tumour cells and the associated regulatory mechanisms remain unclear. We investigated VISTA expression and function in tumour cells, and evaluated its mechanism and activity.<h4>Methods</h4>VISTA in tumour cells was assessed by tissue microarray analysis, immunohistochemical staining and western blot. A series of in vitro assays were used to determine the fu ...[more]