Ontology highlight
ABSTRACT:
SUBMITTER: Gao M
PROVIDER: S-EPMC6325157 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Gao Mei M Lin Miranda M Moffitt Richard A RA Salazar Marcela A MA Park Jinha J Vacirca Jeffrey J Huang Chuan C Shroyer Kenneth R KR Choi Minsig M Georgakis Georgios V GV Sasson Aaron R AR Talamini Mark A MA Kim Joseph J
British journal of cancer 20181031 1
<h4>Background</h4>Pancreatic cancer (PC) hijacks innate cellular processes to promote cancer growth. We hypothesized that PC exploits PD-1/PD-L1 not only to avoid immune responses, but to directly enhance growth. We also hypothesized that immune checkpoint inhibitors (ICIs) have direct cytotoxicity in PC. We sought to elucidate therapeutic targeting of PD-1/PD-L1.<h4>Methods</h4>PD-1 was assessed in PC cells, patient-derived organoids (PDOs), and clinical tissues. Then, PC cells were exposed to ...[more]