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Genetic Correlation of Antibiotic Susceptibility and Resistance Genotyping for the Mycobacterium abscessus Group.

ABSTRACT: Treatment efficacy of Mycobacterium abscessus infections depends on bacterial genotype. Here, the relationship between genotype, as determined by sequence analysis, and antibiotic resistance phenotype was analyzed. The results demonstrate that M. abscessus genotype characteristics, including erm(41) sequevar and mutations of rrl and rrs, are predictive of clarithromycin and amikacin resistance.

SUBMITTER: Zheng H 

PROVIDER: S-EPMC6325201 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Genetic Correlation of Antibiotic Susceptibility and Resistance Genotyping for the <i>Mycobacterium abscessus</i> Group.

Zheng Huiwen H   Liu Dongxin D   Lu Jie J   Song Yuanyuan Y   Wang Shengfen S   Zhao Yanlin Y   Ni Xin X  

Antimicrobial agents and chemotherapy 20181221 1

Treatment efficacy of <i>Mycobacterium abscessus</i> infections depends on bacterial genotype. Here, the relationship between genotype, as determined by sequence analysis, and antibiotic resistance phenotype was analyzed. The results demonstrate that <i>M. abscessus</i> genotype characteristics, including <i>erm</i>(41) sequevar and mutations of <i>rrl</i> and <i>rrs</i>, are predictive of clarithromycin and amikacin resistance. ...[more]

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