Ontology highlight
ABSTRACT:
SUBMITTER: Park EJ
PROVIDER: S-EPMC6325302 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Park Eun Jeong EJ Prajuabjinda Onmanee O Soe Zay Yar ZY Darkwah Samuel S Appiah Michael G MG Kawamoto Eiji E Kawamoto Eiji E Momose Fumiyasu F Shiku Hiroshi H Shimaoka Motomu M
Blood advances 20190101 1
Exosomes secreted from T cells have been shown to affect dendritic cells, cancer cells, and other T cells. However, little is known about how T-cell exosomes (T exosomes) modulate endothelial cell functions in the context of tissue-specific homing. Here, we study the roles of T exosomes in the regulation of gut-specific T-cell homing. The gut-tropic T cells induced by retinoic acid secrete the exosomes that upregulate integrin α4β7 binding to the MAdCAM-1 expressed on high endothelial venules in ...[more]