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Diverse Lineages of Candida albicans Live on Old Oaks.


ABSTRACT: The human pathogen Candida albicans is considered an obligate commensal of animals, yet it is occasionally isolated from trees, shrubs, and grass. We generated genome sequence data for three strains of C. albicans that we isolated from oak trees in an ancient wood pasture, and compared these to the genomes of over 200 clinical strains. C. albicans strains from oak are similar to clinical C. albicans in that they are predominantly diploid and can become homozygous at the mating locus through whole-chromosome loss of heterozygosity. Oak strains differed from clinical strains in showing slightly higher levels of heterozygosity genome-wide. Using phylogenomic analyses and in silico chromosome painting, we show that each oak strain is more closely related to strains from humans and other animals than to strains from other oaks. The high genetic diversity of C. albicans from old oaks shows that they can live in this environment for extended periods of time.

SUBMITTER: Bensasson D 

PROVIDER: S-EPMC6325710 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Diverse Lineages of <i>Candida albicans</i> Live on Old Oaks.

Bensasson Douda D   Dicks Jo J   Ludwig John M JM   Bond Christopher J CJ   Elliston Adam A   Roberts Ian N IN   James Stephen A SA  

Genetics 20181121 1


The human pathogen <i>Candida albicans</i> is considered an obligate commensal of animals, yet it is occasionally isolated from trees, shrubs, and grass. We generated genome sequence data for three strains of <i>C. albicans</i> that we isolated from oak trees in an ancient wood pasture, and compared these to the genomes of over 200 clinical strains. <i>C. albicans</i> strains from oak are similar to clinical <i>C. albicans</i> in that they are predominantly diploid and can become homozygous at t  ...[more]

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