Oral polio vaccine response in the MAL-ED birth cohort study: Considerations for polio eradication strategies.

ABSTRACT:

Background

Immunization programs have leveraged decades of research to maximize oral polio vaccine (OPV) response. Moving toward global poliovirus eradication, the WHO recommended phased OPV-to-IPV replacement on schedules in 2012. Using the MAL-ED prospective birth cohort data, we evaluated the influence of early life exposures impacting OPV immunization by measuring OPV response for serotypes 1 and 3.

Methods

Polio neutralizing antibody assays were conducted at 7 and 15 months of age for serotypes 1 and 3. Analyses were conducted on children receiving ≥3 OPV doses (n = 1449). History of vaccination, feeding patterns, physical growth, home environment, diarrhea, enteropathogen detection, and gut inflammation were examined as risk factors for non-response [Log₂(ti

SUBMITTER: Pan WK 

PROVIDER: S-EPMC6325791 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature