Short-term intra-arterial infusion chemotherapy for head and neck cancer patients maintaining quality of life.

ABSTRACT:

Purpose

Head and neck cancer treatment achieves good locoregional tumor control rates while causing severe side effects. Therapy with chemotherapeutic drugs administered intravenously is limited because either the concentrations at the tumor site are too low or the total dosages are too high. The evaluation of a technique for short-term intra-arterial infusion chemotherapy is described herein.

Methods

In a retrospective study, we reviewed the medical records of 97 patients with head and neck cancers who received short-term intra-arterial infusion chemotherapy (62 patients previously untreated, 35 patients with prior radiotherapy). All patients refused further radiotherapy. Response rates, overall survival and adverse effects were the study endpoints. The blood supply of the

SUBMITTER: Aigner KR 

PROVIDER: S-EPMC6325995 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature