Ontology highlight
ABSTRACT:
SUBMITTER: Hoffman M
PROVIDER: S-EPMC6326120 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Hoffman Maureane M Goldstein Joshua N JN Levy Jerrold H JH
International journal of emergency medicine 20181203 1
<h4>Background</h4>Bleeding complications are a risk associated with all anticoagulants. Currently, the treatment options for the management of direct oral anticoagulant (DOAC)-associated bleeding are limited. Prothrombin complex concentrates (PCCs) have been proposed as a potential therapeutic option, and evidence regarding their use is increasing.<h4>Review</h4>Many studies supporting PCC have used preclinical models and healthy volunteers; however, more recently, observational studies have fu ...[more]