Ontology highlight
ABSTRACT:
SUBMITTER: Davis M
PROVIDER: S-EPMC6326153 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Scientific data 20190108
To achieve therapeutic goals, many cancer chemotherapeutics are used at doses close to their maximally tolerated doses. Thus, it may be expected that when therapies are combined at therapeutic doses, toxicity profiles may change. In many ways, prediction of synergistic toxicities for drug combinations is similar to predicting synergistic efficacy, and is dependent upon building hypotheses from molecular mechanisms of drug toxicity. The key objective of this initiative was to generate and make pu ...[more]