Unknown

Dataset Information

0

APOBEC3G expression and HIV-1 infection in Burkina Faso.


ABSTRACT: APOBEC3G is a potent inhibitor of HIV-1 replication, and act by deaminating cytidines in uracil on the negative strand of the viral cDNA. In this case-control study, APOBEC3G expression in subjects' naïve to HAART infected by HIV-1 and the effect of APOBEC3G polymorphism on its expression were evaluated. The results show that the HIV-1 infected carriers of the G minor alleles of the variant rs8177832 had a higher expression of APOBEC3G mRNA than the controls carriers of the G minor allele. APOBEC3G polymorphisms could play an important role in the modulation of the HIV-1 dissemination.

SUBMITTER: Compaore TR 

PROVIDER: S-EPMC6326155 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications


APOBEC3G is a potent inhibitor of HIV-1 replication, and act by deaminating cytidines in uracil on the negative strand of the viral cDNA. In this case-control study, <i>APOBEC3G</i> expression in subjects' naïve to HAART infected by HIV-1 and the effect of APOBEC3G polymorphism on its expression were evaluated. The results show that the HIV-1 infected carriers of the G minor alleles of the variant rs8177832 had a higher expression of <i>APOBEC3G</i> mRNA than the controls carriers of the G minor  ...[more]

Similar Datasets

| S-EPMC4704832 | biostudies-literature
| S-EPMC4957463 | biostudies-literature
| S-EPMC3960253 | biostudies-literature
2017-10-02 | GSE100562 | GEO
2017-10-02 | GSE100561 | GEO
| S-EPMC4784410 | biostudies-literature
| PRJEB26839 | ENA
| S-EPMC4622231 | biostudies-literature
| S-EPMC5708222 | biostudies-literature
| S-EPMC3310091 | biostudies-literature