Ontology highlight
ABSTRACT:
SUBMITTER: Enomoto M
PROVIDER: S-EPMC6326241 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Enomoto Masataka M Mantyh Patrick W PW Murrell Joanna J Innes John F JF Lascelles B Duncan X BDX
The Veterinary record 20181027 1
Nerve growth factor (NGF) is essential for the survival of sensory and sympathetic neurons during development. However, in the adult, NGF and its interaction with tropomyosin receptor kinase A receptor (TrkA) has been found to play a critical role in nociception and nervous system plasticity in pain conditions. Thus, various monoclonal antibody (mAb) therapies targeting this pathway have been investigated in the development of new pharmacotherapies for chronic pain. Although none of the mAbs aga ...[more]