Ontology highlight
ABSTRACT:
SUBMITTER: Liu B
PROVIDER: S-EPMC6326783 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Liu Binbin B Maekawa Toshio T Yoshida Keisuke K Ly Nhung Hong NH Inoue Kimiko K Hasegawa Ayumi A Chatton Bruno B Ogura Atsuo A Ishii Shunsuke S
Nucleic acids research 20190101 1
Various stresses increase disease susceptibility and accelerate aging, and increasing evidence suggests that these effects can be transmitted over generation. Epidemiological studies suggest that stressors experienced by parents affect the longevity of their offspring, possibly by regulating telomere dynamics. Telomeres are elongated by telomerase and shortened by certain stresses as well as telomere repeat-containing RNA (TERRA), a telomere transcript. However, the mechanism underlying the tran ...[more]