Ontology highlight
ABSTRACT:
SUBMITTER: Larsen SJ
PROVIDER: S-EPMC6326786 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Larsen Simon J SJ Röttger Richard R Schmidt Harald H H W HHHW Baumbach Jan J
Nucleic acids research 20190101 1
Gene regulatory networks (GRNs) and gene expression data form a core element of systems biology-based phenotyping. Changes in the expression of transcription factors are commonly believed to have a causal effect on the expression of their targets. Here we evaluated in the best researched model organism, Escherichia coli, the consistency between a GRN and a large gene expression compendium. Surprisingly, a modest correlation was observed between the expression of transcription factors and their t ...[more]