Ontology highlight
ABSTRACT:
SUBMITTER: Issitt T
PROVIDER: S-EPMC6327076 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Issitt Theo T Bosseboeuf Emy E De Winter Natasha N Dufton Neil N Gestri Gaia G Senatore Valentina V Chikh Anissa A Randi Anna M AM Raimondi Claudio C
iScience 20181211
The transmembrane protein neuropilin-1 (NRP1) promotes vascular endothelial growth factor (VEGF) and extracellular matrix signaling in endothelial cells (ECs). Although it is established that NRP1 is essential for angiogenesis, little is known about its role in EC homeostasis. Here, we report that NRP1 promotes mitochondrial function in ECs by preventing iron accumulation and iron-induced oxidative stress through a VEGF-independent mechanism in non-angiogenic ECs. Furthermore, NRP1-deficient ECs ...[more]