Accurate prediction of cell type-specific transcription factor binding.
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ABSTRACT:
SUBMITTER: Keilwagen J
PROVIDER: S-EPMC6327544 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Publications
Accurate prediction of cell type-specific transcription factor binding.
Keilwagen Jens J Posch Stefan S Grau Jan J
Genome biology 20190110 1
Prediction of cell type-specific, in vivo transcription factor binding sites is one of the central challenges in regulatory genomics. Here, we present our approach that earned a shared first rank in the "ENCODE-DREAM in vivo Transcription Factor Binding Site Prediction Challenge" in 2017. In post-challenge analyses, we benchmark the influence of different feature sets and find that chromatin accessibility and binding motifs are sufficient to yield state-of-the-art performance. Finally, we provid ...[more]
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