A measure of agreement across numerous conditions: assessing when changes in network structures are tissue-specific.

ABSTRACT:

Background

There is great interest to study how gene pathways change their structure across different tissues. The assessment of inter-study reliability of pathway changes across tissues can inform on the fraction of tissues with specific functional changes in network structure. However, there is a lack of agreement measures among studies that independently observe how a group of observations change across conditions. We, therefore, propose λ, a new inter-study reliability measure that determines the consistency to distinguish observations by condition.

Results

We derived λ's distributional characteristics, determine its reliability properties and compared it with Cohen's κ. We studied the co-expression structure of 287 gene pathways across four brain regions in two transcri

SUBMITTER: Caceres A 

PROVIDER: S-EPMC6327576 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature