Ontology highlight
ABSTRACT:
SUBMITTER: Unsworth AJ
PROVIDER: S-EPMC6327716 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Unsworth Amanda J AJ Bombik Izabela I Pinto-Fernandez Adan A McGouran Joanna F JF Konietzny Rebecca R Zahedi René P RP Watson Steve P SP Kessler Benedikt M BM Pears Catherine J CJ
Thrombosis and haemostasis 20181231 1
Platelet activators stimulate post-translational modification of signalling proteins to change their activity or their molecular interactions leading to signal propagation. One covalent modification is attachment of the small protein ubiquitin to lysine residues in target proteins. Modification by ubiquitin can either target proteins for degradation by the proteasome or act as a scaffold for other proteins. Pharmacological inhibition of deubiquitylases or the proteasome inhibition of platelet ac ...[more]