Ontology highlight
ABSTRACT:
SUBMITTER: Razavi P
PROVIDER: S-EPMC6327853 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Cancer cell 20180901 3
We integrated the genomic sequencing of 1,918 breast cancers, including 1,501 hormone receptor-positive tumors, with detailed clinical information and treatment outcomes. In 692 tumors previously exposed to hormonal therapy, we identified an increased number of alterations in genes involved in the mitogen-activated protein kinase (MAPK) pathway and in the estrogen receptor transcriptional machinery. Activating ERBB2 mutations and NF1 loss-of-function mutations were more than twice as common in e ...[more]