Dataset Information

Cellular evidence for efference copy in Drosophila visuomotor processing.

ABSTRACT: Each time a locomoting fly turns, the visual image sweeps over the retina and generates a motion stimulus. Classic behavioral experiments suggested that flies use active neural-circuit mechanisms to suppress the perception of self-generated visual motion during intended turns. Direct electrophysiological evidence, however, has been lacking. We found that visual neurons in Drosophila receive motor-related inputs during rapid flight turns. These inputs arrived with a sign and latency appropriate for suppressing each targeted cell's visual response to the turn. Precise measurements of behavioral and neuronal response latencies supported the idea that motor-related inputs to optic flow-processing cells represent internal predictions of the expected visual drive induced by voluntary turns. Motor-related inputs to small object-selective visual neurons could reflect either proprioceptive feedback from the turn or internally generated signals. Our results in Drosophila echo the suppression of visual perception during rapid eye movements in primates, demonstrating common functional principles of sensorimotor processing across phyla.

SUBMITTER: Kim AJ

PROVIDER: S-EPMC6327952 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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Cellular evidence for efference copy in Drosophila visuomotor processing.

Kim Anmo J AJ Fitzgerald Jamie K JK Maimon Gaby G

Nature neuroscience 20150803 9

Each time a locomoting fly turns, the visual image sweeps over the retina and generates a motion stimulus. Classic behavioral experiments suggested that flies use active neural-circuit mechanisms to suppress the perception of self-generated visual motion during intended turns. Direct electrophysiological evidence, however, has been lacking. We found that visual neurons in Drosophila receive motor-related inputs during rapid flight turns. These inputs arrived with a sign and latency appropriate f ...[more]

PMID: 26237362

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Project description:Background: Response inhibition engages the cortico-striato-thalamo-cortical (CSTC) circuit, which has been implicated in children, and youth with obsessive compulsive disorder (OCD). This study explored whether CSTC engagement during response inhibition, measured using magnetoencephalography (MEG), differed in a sample of medication-naïve youth with OCD, compared to typically developing controls (TDC). Methods: Data was analyzed in 17 medication-naïve children and youth with OCD (11.7 ± 2.2 SD years) and 13 TDC (12.6 ± 2.2 SD years). MEG was used to localize and characterize neural activity during a Go/No-Go task. Task performance on Go/No-Go conditions and regional differences in amplitude of activity during Go and No-Go condition between OCD vs. TDC were examined using two-sample t-tests. Post-hoc analysis with Bayesian t-tests was used to estimate the certainty of outcomes. Results: No differences in Go/No-Go performance were found between OCD and TDC groups. In response to the visual cue presented during the Go condition, participants with OCD showed significantly increased amplitude of activity in the primary motor (MI) cortex compared to TDC. In addition, significantly reduced amplitude of PCu was found following successful stopping to No-Go cues in OCD vs. TDC during No-Go task performance. Bayesian t-tests indicated high probability and large effect sizes for the differences in MI and PCu amplitude found between groups. Conclusion: Our preliminary study in a small medication-naïve sample extends previous work indicating intact response inhibition in pediatric OCD. While altered neural response in the current study was found during response inhibition performance in OCD, differences localized to regions outside of the CSTC. Our findings suggest that additional imaging research in medication-naïve samples is needed to clarify regional differences associated with OCD vs. influenced by medication effects, and suggest that MEG may be sensitive to detecting such differences.

Dataset Information

Cellular evidence for efference copy in Drosophila visuomotor processing.

Publications

Cellular evidence for efference copy in Drosophila visuomotor processing.

Similar Datasets

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