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Emergence of Madariaga virus as a cause of acute febrile illness in children, Haiti, 2015-2016.


ABSTRACT: Madariaga virus (MADV), also known as South American eastern equine encephalitis virus, has been identified in animals and humans in South and Central America, but not previously in Hispaniola or the northern Caribbean. MADV was isolated from virus cultures of plasma from an 8-year-old child in a school cohort in the Gressier/Leogane region of Haiti, who was seen in April, 2015, with acute febrile illness (AFI). The virus was subsequently cultured from an additional seven AFI case patients from this same cohort in February, April, and May 2016. Symptoms most closely resembled those seen with confirmed dengue virus infection. Sequence data were available for four isolates: all were within the same clade, with phylogenetic and molecular clock data suggesting recent introduction of the virus into Haiti from Panama sometime in the period from October 2012-January 2015. Our data document the movement of MADV into Haiti, and raise questions about the potential for further spread in the Caribbean or North America.

SUBMITTER: Lednicky JA 

PROVIDER: S-EPMC6328082 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Emergence of Madariaga virus as a cause of acute febrile illness in children, Haiti, 2015-2016.

Lednicky John A JA   White Sarah K SK   Mavian Carla N CN   El Badry Maha A MA   Telisma Taina T   Salemi Marco M   OKech Bernard A BA   Beau De Rochars V Madsen VM   Morris J Glenn JG  

PLoS neglected tropical diseases 20190110 1


Madariaga virus (MADV), also known as South American eastern equine encephalitis virus, has been identified in animals and humans in South and Central America, but not previously in Hispaniola or the northern Caribbean. MADV was isolated from virus cultures of plasma from an 8-year-old child in a school cohort in the Gressier/Leogane region of Haiti, who was seen in April, 2015, with acute febrile illness (AFI). The virus was subsequently cultured from an additional seven AFI case patients from  ...[more]

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