Ontology highlight
ABSTRACT:
SUBMITTER: Ortiz Zacarias NV
PROVIDER: S-EPMC6328288 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20181011 20
The recent crystal structures of CC chemokine receptors 2 and 9 (CCR2 and CCR9) have provided structural evidence for an allosteric, intracellular binding site. The high conservation of residues involved in this site suggests its presence in most chemokine receptors, including the close homologue CCR1. By using [<sup>3</sup>H]CCR2-RA-[ R], a high-affinity, CCR2 intracellular ligand, we report an intracellular binding site in CCR1, where this radioligand also binds with high affinity. In addition ...[more]