A Host-Produced Quorum-Sensing Autoinducer Controls a Phage Lysis-Lysogeny Decision.
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ABSTRACT:
SUBMITTER: Silpe JE
PROVIDER: S-EPMC6329655 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Publications
A Host-Produced Quorum-Sensing Autoinducer Controls a Phage Lysis-Lysogeny Decision.
Silpe Justin E JE Bassler Bonnie L BL
Cell 20181213 1-2
Vibrio cholerae uses a quorum-sensing (QS) system composed of the autoinducer 3,5-dimethylpyrazin-2-ol (DPO) and receptor VqmA (VqmA<sub>Vc</sub>), which together repress genes for virulence and biofilm formation. vqmA genes exist in Vibrio and in one vibriophage, VP882. Phage-encoded VqmA (VqmA<sub>Phage</sub>) binds to host-produced DPO, launching the phage lysis program via an antirepressor that inactivates the phage repressor by sequestration. The antirepressor interferes with repressors fro ...[more]
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