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Magnusiomyces clavatus infection in a child after allogeneic hematotopoetic stem cell transplantation: Diagnostic and therapeutic implications.

ABSTRACT: Magnusiomyces clavatus is an ascomycetous fungus causing invasive disease in immuno-compromised patients. Neutropenia, contaminated venous catheters, previous antifungal treatment are risk factors for this infection. We report a case of Magnusiomyces clavatus fungemia with pulmonary, renal and skin localizations in a 6-year-old boy with prolonged neutropenia because of three allogeneic hematopoietic stem cell transplantations. The infection was controlled by aggressive and strictly monitored combination therapy with voriconazole and liposomial-ampthotericine-B along with durable recover from neutropenia.

SUBMITTER: Leoni M

PROVIDER: S-EPMC6329693 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Magnusiomyces clavatus infection in a child after allogeneic hematotopoetic stem cell transplantation: Diagnostic and therapeutic implications.

Leoni Massimiliano M Riccardi Niccolò N Rotulo Gioacchino Andrea GA Godano Elisabetta E Faraci Maura M Bandettini Roberto R Esposto Maria Carmela MC Castagnola Elio E

Medical mycology case reports 20181221

<i>Magnusiomyces clavatus</i> is an ascomycetous fungus causing invasive disease in immuno-compromised patients. Neutropenia, contaminated venous catheters, previous antifungal treatment are risk factors for this infection. We report a case of <i>Magnusiomyces clavatus</i> fungemia with pulmonary, renal and skin localizations in a 6-year-old boy with prolonged neutropenia because of three allogeneic hematopoietic stem cell transplantations. The infection was controlled by aggressive and strictly ...[more]

PMID: 30656133

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