Dataset Information

3DPatch: fast 3D structure visualization with residue conservation.

ABSTRACT: Summary:Amino acid residues showing above background levels of conservation are often indicative of functionally significant regions within a protein. Understanding how the sequence conservation profile relates in space requires projection onto a protein structure, a potentially time-consuming process. 3DPatch is a web application that streamlines this task by automatically generating multiple sequence alignments (where appropriate) and finding structural homologs, presenting the user with a choice of structures matching their query, annotated with residue conservation scores in a matter of seconds. Availability and implementation:3DPatch is written in JavaScript and is freely available at http://www.skylign.org/3DPatch/. Mozilla Firefox, Google Chrome, and Safari web browsers are supported. Source code is available under MIT license at https://github.com/davidjakubec/3DPatch. Supplementary information:Supplementary data are available at Bioinformatics online.

SUBMITTER: Jakubec D

PROVIDER: S-EPMC6330005 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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3DPatch: fast 3D structure visualization with residue conservation.

Jakubec David D Vondrášek Jirí J Finn Robert D RD

Bioinformatics (Oxford, England) 20190101 2

<h4>Summary</h4>Amino acid residues showing above background levels of conservation are often indicative of functionally significant regions within a protein. Understanding how the sequence conservation profile relates in space requires projection onto a protein structure, a potentially time-consuming process. 3DPatch is a web application that streamlines this task by automatically generating multiple sequence alignments (where appropriate) and finding structural homologs, presenting the user wi ...[more]

PMID: 29931189

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Dataset Information

3DPatch: fast 3D structure visualization with residue conservation.

Publications

3DPatch: fast 3D structure visualization with residue conservation.

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