Ontology highlight
ABSTRACT:
SUBMITTER: Assi SA
PROVIDER: S-EPMC6330064 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Nature genetics 20181112 1
Acute myeloid leukemia (AML) is a heterogeneous disease caused by a variety of alterations in transcription factors, epigenetic regulators and signaling molecules. To determine how different mutant regulators establish AML subtype-specific transcriptional networks, we performed a comprehensive global analysis of cis-regulatory element activity and interaction, transcription factor occupancy and gene expression patterns in purified leukemic blast cells. Here, we focused on specific subgroups of s ...[more]