SLIMEr: probing flexibility of lipid metabolism in yeast with an improved constraint-based modeling framework.
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ABSTRACT:
SUBMITTER: Sanchez BJ
PROVIDER: S-EPMC6330394 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Publications
SLIMEr: probing flexibility of lipid metabolism in yeast with an improved constraint-based modeling framework.
Sánchez Benjamín J BJ Li Feiran F Kerkhoven Eduard J EJ Nielsen Jens J
BMC systems biology 20190111 1
<h4>Background</h4>A recurrent problem in genome-scale metabolic models (GEMs) is to correctly represent lipids as biomass requirements, due to the numerous of possible combinations of individual lipid species and the corresponding lack of fully detailed data. In this study we present SLIMEr, a formalism for correctly representing lipid requirements in GEMs using commonly available experimental data.<h4>Results</h4>SLIMEr enhances a GEM with mathematical constructs where we Split Lipids Into Mea ...[more]
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