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ABSTRACT: Background
Cardiovascular magnetic resonance (CMR) myocardial native T1 mapping allows assessment of interstitial diffuse fibrosis. In this technique, the global and regional T1 are measured manually by drawing region of interest in motion-corrected T1 maps. The manual analysis contributes to an already lengthy CMR analysis workflow and impacts measurements reproducibility. In this study, we propose an automated method for combined myocardium segmentation, alignment, and T1 calculation for myocardial T1 mapping.Methods
A deep fully convolutional neural network (FCN) was used for myocardium segmentation in T1 weighted images. The segmented myocardium was then resampled on a polar grid, whose origin is located at the center-of-mass of the segmented myocardium. Myocardium T1 maps were reconstructed from the resampled T1 weighted images using curve fitting. The FCN was trained and tested using manually segmented images for 210 patients (5 slices, 11 inversion times per patient). An additional image dataset for 455 patients (5 slices and 11 inversion times per patient), analyzed by an expert reader using a semi-automatic tool, was used to validate the automatically calculated global and regional T1 values. Bland-Altman analysis, Pearson correlation coefficient, r, and the Dice similarity coefficient (DSC) were used to evaluate the performance of the FCN-based analysis on per-patient and per-slice basis. Inter-observer variability was assessed using intraclass correlation coefficient (ICC) of the T1 values calculated by the FCN-based automatic method and two readers.Results
The FCN achieved fast segmentation (1 values (1091?±?59?ms and 1089?±?59?ms, respectively) were highly correlated in per-patient (r?=?0.82; slope?=?1.01; p?1 calculations by the automatic method vs reader 1 and reader 2 was respectively 0.86/0.56 and 0.74/0.49 in the per-patient/per-slice analyses, which were comparable to that between two expert readers (=0.72/0.58 in per-patient/per-slice analyses).Conclusion
The proposed FCN-based image processing platform allows fast and automatic analysis of myocardial native T1 mapping images mitigating the burden and observer-related variability of manual analysis.
SUBMITTER: Fahmy AS
PROVIDER: S-EPMC6330747 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Fahmy Ahmed S AS El-Rewaidy Hossam H Nezafat Maryam M Nakamori Shiro S Nezafat Reza R
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 20190114 1
<h4>Background</h4>Cardiovascular magnetic resonance (CMR) myocardial native T<sub>1</sub> mapping allows assessment of interstitial diffuse fibrosis. In this technique, the global and regional T<sub>1</sub> are measured manually by drawing region of interest in motion-corrected T<sub>1</sub> maps. The manual analysis contributes to an already lengthy CMR analysis workflow and impacts measurements reproducibility. In this study, we propose an automated method for combined myocardium segmentation ...[more]