SPINK1 promotes cell growth and metastasis of lung adenocarcinoma and acts as a novel prognostic biomarker.
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ABSTRACT:
SUBMITTER: Xu L
PROVIDER: S-EPMC6330943 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Publications
SPINK1 promotes cell growth and metastasis of lung adenocarcinoma and acts as a novel prognostic biomarker.
Xu Liyun L Lu Changchang C Huang Yanyan Y Zhou Jihang J Wang Xincheng X Liu Chaowu C Chen Jun J Le Hanbo H
BMB reports 20181201 12
Serine protease inhibitor Kazal type 1 (SPINK1) plays a role in protecting the pancreas against premature activation of trypsinogen and is involved in cancer progression. SPINK1 promoted LAC cells growth, migration, and invasion. Mechanistically, we found that SPINK1 promoted LAC cells migration and invasion via up-regulating matrix metalloproteinase 12 (MMP12). We observed that SPINK1 expression was only up-regulated in lung adenocarcinoma (LAC) tissues, and was an independent prognostic factor ...[more]
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