Ontology highlight
ABSTRACT:
SUBMITTER: Wu Z
PROVIDER: S-EPMC6331155 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20181231 1
A series of new angiotensin II receptor 1 antagonists were prepared. They displayed nanomolar affinity to AT<sub>1</sub> receptor and could decrease blood pressure efficiently in spontaneously hypertensive rats. Among them, compounds <b>1b</b> and <b>2b</b> could reduce the blood pressure with more or equal potency compared to Losartan. So, compounds <b>1b</b> and <b>2b</b> could be considered as potential antihypertension drug candidates. ...[more]