Ontology highlight
ABSTRACT:
SUBMITTER: Mansour AA
PROVIDER: S-EPMC6331203 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Mansour Abed AlFatah AA Gonçalves J Tiago JT Bloyd Cooper W CW Li Hao H Fernandes Sarah S Quang Daphne D Johnston Stephen S Parylak Sarah L SL Jin Xin X Gage Fred H FH
Nature biotechnology 20180416 5
Differentiation of human pluripotent stem cells to small brain-like structures known as brain organoids offers an unprecedented opportunity to model human brain development and disease. To provide a vascularized and functional in vivo model of brain organoids, we established a method for transplanting human brain organoids into the adult mouse brain. Organoid grafts showed progressive neuronal differentiation and maturation, gliogenesis, integration of microglia, and growth of axons to multiple ...[more]