Ontology highlight
ABSTRACT:
SUBMITTER: Tuukkanen AT
PROVIDER: S-EPMC6331215 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Tuukkanen Anne T AT Freire Diana D Chan Sum S Arbing Mark A MA Reed Robert W RW Evans Timothy J TJ Zenkeviciutė Grasilda G Kim Jennifer J Kahng Sara S Sawaya Michael R MR Chaton Catherine T CT Wilmanns Matthias M Eisenberg David D Parret Annabel H A AHA Korotkov Konstantin V KV
Journal of molecular biology 20181110 2
Type VII secretion systems (ESX) are responsible for transport of multiple proteins in mycobacteria. How different ESX systems achieve specific secretion of cognate substrates remains elusive. In the ESX systems, the cytoplasmic chaperone EspG forms complexes with heterodimeric PE-PPE substrates that are secreted from the cells or remain associated with the cell surface. Here we report the crystal structure of the EspG<sub>1</sub> chaperone from the ESX-1 system determined using a fusion strateg ...[more]